Chattanooga, TN, USA
http://www.jfpsinfo.org/

The Joint Forces Pharmacy Seminar (JFPS) is being held by the Joint Forces and according to their website,  ”is the largest annual event for the Army, Navy, Air Force and Coast Guard pharmacy community…”

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Germfree will be exhibiting and demonstrating a range of equipment for the hospital and healthcare pharmacist.  Germfree manufactures Compounding Aseptic Isolators (CAI), Laminar Airflow Workstations, and Biological Safety Cabinets, including a range of equipment that complies with USP 797.

The most recent edition of CBRNe WORLD Magazine includes a highly informative article on the rationale for the procurement and deployment of mobile laboratories. The article, authored by Monica Heyl, discusses the use of mobile labs by first responders, military, law enforcement and civil support teams.  Ms. Heyl describes a range of applications for these units:

“Mobile laboratories can be integrated to fill a wide variety of challenges: sample receipt, screening and evaluating suspect unknown materials, environmental health protection and remediation, narcotics analysis and confirmation of clandestine laboratories. They can respond to catastrophes, terrorism, and a myriad of other actions in theatres of conflict or on our own homelands.” 

The CBRNe World article also discusses the critical role of proper engineering controls in mobile laboratories, stating that:

“Engineering controls (primary and secondary) become vital to sample collection, reception, preparation, analysis and spent effluent that could contaminate the environment. Robust engineering controls to include redundant and hybrid filtration systems, breakthrough monitors and backup uninterrupted power are only as good as the quality assurances associated with the development, building, manufacturing and testing of such safeguards.”

The article, “Mobile Laboratories: Do They Know Their Rank,” by Monica Heyl is available in the Spring 2010 edition of CBRNe World Magazine.

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Monica Heyl is an internationally recognized mobile laboratory expert.  She Co-founded,  Monica Heyl and Associates after retiring from the United States Department of Defense, US Army. This firm specializes in field analytical solutions particularly in high hazard environments. Her 35 years of service included a range of leadership positions, including: US Army Senior Leader; Director of International Programs and Leader of the US Army’s Mobile Laboratory & Kits (ML&K) Team and the Advanced CBRNE Training Team.

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 CBRNe World  is a internationally distributed quarterly publication based in the UK. The magazine is geared for professionals in a range of fields where their work involves “planning for or responding to a chemical, biological, radiological, nuclear or explosives (CBRNe) threat or incident.”  According to the publishers, the CBRNe World content spans the “divide of operational and scientific, it brings together opinion formers from the world of civil response, military leaders, academia, government agencies, research labs and industry.”

Three events have come together in the past few years that codified a need for rapidly deployable, mobile and cost effective containment equipment.  First, there was recognition that many regions and countries in the world did not have adequate infrastructure, reliable power, or primary containment to provide a safe environment when working with emerging, re-emerging and dangerous infectious agents. In the US and elsewhere following the 2001 anthrax letters Public Health Labs and First Responders began experiencing an increase in their mission scope to collect, transport and perform analysis on unknown samples that may contain biological or chemical hazards. That mission had increased significantly due to copycat, hoax and criminal activity.  In the same timeframe, advances in biomedical research created a need to move samples, animals and materials from room to room, or into and out of imaging suites and equipment while maintaining containment.  In response to these needs portable Class III Biosafety Cabinets, flexible film isolators and compact, easily deployable hybrids were developed and refined.

Portable Class III Biological Safety Cabinet

SEA benchtop (Portable)

Small, bench top units were developed that provide safe, effective and affordable primary containment (i.e. SEA) enabling flexibility for laboratory use or field deployment. It was originally developed for diagnostic screening of unknown and highly pathogenic samples in facilities, laboratories or field settings that lack reliable secondary containment controls.  The closed system decreases the chance of aerosol escape, resultant accidental exposure and potential laboratory acquired illnesses.   

In animal research, portable battery powered Class III BSCs are increasingly being used to move animals from holding rooms to procedure rooms.  The supply is single HEPA filtered, the exhaust is double HEPA filtered as required by the CDC (Download BMBL 5th Ed. pdf).  By use of large RTPs integrated into transporter carts of Class III design, the walls of animal holding rooms, and stationary Class III systems, scientists can safely transport exposed animals from holding rooms to procedure areas equipped with devices such as magnetic resonance imaging (MRI), positron emission tomography (PET), and other non-invasive scanning devices. The systems reduce personnel and environmental exposure and reduce the time the animal must be handled and anesthetized.

 

Class III animal transfer with RTP dock

SEA with passthrough and legs built in

        

 

 

 

 

 

 

 

Transportable Class III BSC

All hazard reciept Transportable Class III Biological Safety Cabinet

Transportable Class III Biological Safety Cabinets are used in Public Health Laboratories for the receipt of unknown hazardous samples associated with chemical or biological terrorism or criminal activities.  Workers use the transport BSCs to move the unknown hazardous sample from the loading dock area or other delivery site used by the First Responder, to the containment lab without risking contamination of non-contained and public areas, as well as the containment lab itself.

Taken together, the advent of the use of transport and mobile Class III BSCs provides a significantly safer way of moving and handling infected animals or unknown samples than any past capability.

 

 

Flexible Film Isolator

Transportable flexible film isolator

The negative-pressure flexible-film isolator is a self-contained primary containment device that provides maximum protection against hazardous biological materials. Isolators can be placed on a counter top or on a mobile cart. The workspace is enclosed in a transparent polyvinylchloride (PVC) film that suspended from a plastic or steel framework. Like Class III BSC, the supply air passes through one HEPA filter and exhaust air passes through two HEPA  filters.

WHO recognizes the double HEPA exhaust obviates the need to duct exhaust air outside the building.  Flexible-film isolators are used frequently and very successfully in animal containment, field work and other instances where it is not feasible to install or maintain conventional BSC.  Hybrids (semi-flexible film isolators) exist where some of the panels are made of a rigid material such as polycarbonate, and typically the front panel is soft PVC.

 

 Deployable Isolators 

Field deployable flexible isolator

The deployable isolator unit is a self-contained negative pressure filtration system that operates on two standard D cell batteries.  Supply air is HEPA filtered. Exhaust air is double HEPA or double HEPA and carbon filtered. All filters are readily available and easily replaceable by First Responders and those involved in field collection and preliminary screening and triage. It is a rapidly deployable, light-weight, disposable system that comes in a compact transport case and sets up much like a dome tent. The isolator is made of durable 15mil polyurethane to withstand field use, repeated assembly/disassembly, and can be assembled and operational within minutes for on-demand use requirements.  Large samples and equipment are introduced through a zipper system similar to those on a BSL-4 suit.  Sampling ports are provided for use with external detectors and analytical equipment.         

The diversity in containment equipment is almost limitless and depends on user requirements and design team innovation and advances in materials.